Hi I am getting only 40% of the drug absorbed? is this right? Also, let me know if you need more information from my side.
Quite possibly - it depends on the compound you are dosing some drugs have even lower effective bioavailability, e.g. pyridostigmine (around 7.5% I believe because it is poorly absorbed and largely excreted unchanged and domperidone (~17%). as it has a high first pass effect. Hope that helps. Simon.
Hi Simone, Thanks for your response.. The drug i am using is Paracetamol and we are using Saliva to measure the levels. Also, i am using simulated IV infusion as a reference formulation. If i am using oral as a “Reference Data type” my output is different. If i am right the bio availability is influencing the levy plot and thats the difference i am seeing in the plot am i right. kid regards Mouli
Yes it sounds like it, would be much easier to confirm if you post your project as an attachment to double check your settings. I believe paracetamol’s oral bioavailability (~70-90%) is somewhat dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity. Simon