Modeling Extended/slow Release Formulation

Phoenix Certara Forums Modelling and Simulation
1

Hello,

I am trying to build a pop-pk model for an extended/slow release formulation that was administered at 5 mg/kg Intraperitoneal injection ( IP )

I tried several models like Enterohepatic Recirculation , Transit model , change in absorption rate model and Multiple Absorption Routes (like modeling buccal Nitroglycerin ) .

Yet none of these models described the observed data correctly

Can someone look at the attached file and see what I am doing wrong .

https://drive.google.com/drive/folders/1qRR5bKC0qGeAO_-bQ2K6thGxDp66-Z-8?usp=sharing

Thank you ,

Wafaa

2

I have troubles opening the link. Would you be able to upload the file directly to the forum. Alternatively, you could send to support@certara.com as attachment.

Thanks,

Bernd

3

I wasn’t able to upload it directly to the forum , I will send it to the support@certara.com in an email with the same title. Thank you