Modeling TMDD in Phoenix

[Mukesh_Kumar]

Hi all,

I’ve been having a few issues modeling drugs that suffer from rapid target mediated disposition. Essentially w/severe TMDD we see a 1-2 log drop in first 24-48 hours, then multi-day recovery of serum drug levels and negligible elimination, followed by a first order elimination around day(s) 7-10.

Has anybody successfully modeled these triphasic elimination scenarios in Phoenix? Any tips on the model/compartment structure?
I want to avoid going to Matlab for, well, lazy reasons.

Below is an example using hEPO:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157300/

Thanks in advance!

[Samer_Mouksassi]

Hi did you try to code it into PML and give it a shot there is no way to predict that a minimization engine would file without trying. I am not sure what minimization algorithms are available in Matlab you can always tweak some of the solver tolerance parameter to get to what you want