hi everyone, I need your skills :).
First, I will explain the context of my study.
So we have an X ** drug that was administered as an IV bolus once a week at the same dose D for 5 weeks. Blood samples were taken monthly for 5 months from the last injection. And the drug concentration in the plasma was assayed.
My aim it’s about get PK and biodistribution information for this drug
I read in several articles that the pharmacokinetics of this drug is fitted by a three compartments model.
With only concentration values ​​during the elimination phase and the residual method, I would like to know if it is possible to extrapolate, using the following equation
( C(t)= Som Di (Ae-al(t-tdi)+Be-be(t-tdi)+Ce-ga(t-tdi)) the values ​​of plasma concentrations of X ** drug during the phase Injection.
This would allow me to describe the evolution of plasma concentration over time and to determine the evolution of tissue concentration in the superficial peripheral compartment and the deep peripheral compartment.
Do you think that this approach will allow me to obtain tissue kinetic parameters from plasma data? I must be able to estimate tissue clearance and a mean exposure (AUC).
Can you tell me which approach would be the most optimal in this case?
The idea of simulating the injection phase would make it possible to have an idea of the plasma concentration so I could estimate several pharmacokinetic parameters which will allow me to study the biodistribution of this drug.
I would like to use Phoenix Winonlin for that but I don’t know how to do .
Please can u take a minute of your time and take a look !
Thanks to you,
MHPK.