Dear all, How to setup the NCA model when the dosing interval is unequal. Say TIB before each meal for 5 days. Anyone has experience on this? Thanks in advance. Daniel. 2013-12-13
Daniel, the problem is that NCA theory only supports calcualtion of parameters like Volume and Clearance in one of two states; naive single dose or steady state after regular dosing. If you dosing period is irregular you cannot be sure of these dose & dependent parameters; I would advise avoiding such protocols if you wish to use NCA techniques; or you can choose to try and fit the data with a compartmental model. Simon.