Need some help (IVIVC w mean Data)

Phoenix Certara Forums IVIVC
1

Hi,

I made an attempt to generate an IVIVR based on two ER test formulations and encountered a few problems.

  1. The dissolution profiles failed to fit any of the model in Phoenix

  2. I tried using raw data to generate the IVIVC but failed.

Please assist? The drug is poorly absorbed with BA of ~ 7%

Oral data was obtained as 60 mg but i normalized the dose to 180 mg (the ER is 180 mg).

Is it possible to generate some sort of correlation?

Thank you.

John

P.S. Sorry I made a typo on the dataset names. the in-vitro is actually the in-vivo data and the in-vivo is the in-vitro data.

P-Project.phxproj (46.1 KB)

2

Hi John, the project posted is just the data, do you have a project where you have the workflow set up? to save people a little time in replicating your work and see what you’d already done.

Simon.

3

Thanks Simon. I will set it up and repost.

John