Hi,
I have an established popPK model, how do I get the post hoc exposure estimates for Cmax, Cmin, and AUC of each subject in the model. Thanks
Hi Colby, If you are using a built in model then you can probably easily get these secondary parameters by using the SET WNL model option; if you haven’t seen this before then check the manual or look at https://support.certara.com/forums/topic/753-secondary-parameters
if you need AUC from any differential equation model then you can use
deriv(myAUC = C)
and then including it in a table, as has been discussed in previous posts; https://support.certara.com/forums/topic/192-integration-for-auc-in-pml-model/?p=614
or Cmax here…
https://support.certara.com/forums/topic/721-pml-calculate-max-value-in-compartment
and you can also find time above a threshold; https://support.certara.com/forums/topic/810-time-above-threshold
alternatively you could calculate them after using a data wizard, other data tools eg desc. stats if you request a fine enough grid in a table statement.
https://support.certara.com/forums/topic/740-aucf
Simon.