Summarizing in PML code

Phoenix Certara Forums Modelling and Simulation
1

Dear all

I have a popPK model in which I estimate exposure for each subject with deriv(AUCi=C1Conc).

I would like to report - as a secondary paramer - the geometric mean of AUCi across all the n subjects in the study.

Is there a way to do this in PML code - w/o a Table01 dump and subsequent steps to calculate it?

Thx Thomas

2

Hi Thomas, depending on what model you are using this should be possible. If you are using a built-in model, have you tried the “set WNL model” option ?

If for instance I set model 3 (1com extravascular) the line

secondary(AUC = AaDose/tvV/Ke)

would be added.

Note this is dependent on the last subjects Dose, so if you have different doses in your group there could be issues.

and of course if your model gets more complicated you are going to have to ensure that your formula still holds but please try it and let us know how you get on.

Simon.