Non-linear correlation using IVIVC Toolkit

Phoenix Certara Forums IVIVC
1

Hi,

I am working on IVIVC case for modified release product, and I am able to get only linear correlation FraAbs vs FraDiss (using IVIVC Toolkit).

However, it’s likely that there is a correlation, but not linear.

Questions:

Is there a possibility to get non-linear equation using IVIVC Toolkit?

How to do that?

Is it possible to set one correlation equation up to e.g. 20% dissolved, and another correlation equation for later ?

Thanks in advance

Senka

2

Sure Senka it’s possible; Select the User Specified option button to create a custom correlation model using the WinNonlin ASCII modeling language. There is some info in the Phoenix IVIVC Toolkit 2.2 User’s Guide.pdf as well an example of custom code on here;

http://www.certara.com/forums/topic/563-publications-and-posters/?hl=aaps

Please let us know how you get on.

Simon.

3

Someone recently asked for more details on the ASCII code to help with writing their IVIVC user models, for those of you that this would help; please look at Chapter 10, User Models in the attached WinNonlin 5.3 User guide.

Simon.

WinNonlin User’s Guide 5.3.pdf (5.17 MB)

4

Hello Simon,

Can you share an example code for doing the same or example project

Regards

Harish

5

Harish, please follow the link in post number 2!

Simon.

6

Hello Simon,

I have read an article on “developing Nonlienar IVIVC for Upadacitinib” where the authors have used A user-specified non-linear IVIVC was evaluated by fitting a non-linear Emax model to scale the Tvitro to the Tvivo,

How can we code the same in IVIVC, any insights will help

Link to the paper

https://link.springer.com/article/10.1208/s12248-019-0378-y

Regards

Harish

7

Dear all

I’m also trying to build a non-linear correlation using Upadacitinib paper as example. In the paper a non-linear Emax model to scale the Tvitro to the Tvivo was implemented:

Tvitro = ((A1*Tvivo)/(A2+Tvivo))-B2

I’m using the following code:

T = ((A1 * X)/(A2 * X))
IF T > 0 THEN
DISS = IVINTERP(T)
ELSE
DISS = 0
ENDIF
F = A1 * DISS

When checking, a message shows up:

*** ERROR 10031 *** ATTEMPT TO DIVIDE BY ZERO. PROGRAM TERMINATED. Line = 3: Variable = -------------------------------------------------------------------OK

And it is not possible to Build Correlation.

Any suggestion how to implement such a non linear time scaling?

8

Nuno can you email your project to support@certara.com for us to take a look.