Phoenix 8.6 - Faster optimization for parameters with ADPO

Phoenix
1

Phoenix 8.6 is now available for download, as well as the corresponding Integral 25.4.1 plug-in if required. If you are a hosted Phoenix customer please contact support to be scheduled for upgrading.

https://help.certara.net/en/articles/11628061-what-is-new-in-phoenix-8-6

Log into Certara Admin to read more about the great new features as well as some enhancements/fixes including;

  • Phoenix installer now includes PK Submit

  • NCA enhancements:

  • Automated flagging of data based on sample size, span, and other criteria.

  • New dose-normalized parameters in NCA

  • NLME enhancements:

  • Fast estimation of initial estimates for NLME

  • Fast optimization for parameters with the implementation of ADPO (Automatic Differentiating assisted Parametric Optimization)

  • Data Wizard enhancements:

  • New functions available: lag, first, last, cumulative, fill, split

  • New Description field allows you to describe the purpose of each step in the workflow

  • Tables enhancements:

  • Ability to add combined statistics

  • Apply small sample size rules to statistics calculations

Simon.

https://help.certara.net/en/articles/11542780-introducing-phoenix-8-6

2

We have downloaded and used Phoenix version 8.6, which is available now for customer.

I am still facing issues with the date format when I import and export files in the new Phoenix version 8.6.

My date issue is resolved in the new version, but the time issue is not resolved.

The date format is 23:04, which means it is in 24-hour clock format. However, when I import this file into the new Phoenix version 8.6, the format has changed. The time in FANLETM has changed from 23:04 to 11:04:00, so it is very confusing to identify morning and evening time points. Because Phoenix converted 23:04 hours to 11:04:00, and there is also a 11:00 morning sample present at 11:00:00. Therefore, it is difficult to identify the sample times. So, can you let me know how we can resolve this issue?

3

Hi Vivek, the forum is really for sharing tips and tricks between users like new model code etc.
What you are experiencing sounds like a support issue, please email support@certara.com with an example file that exhibits this issue and we will get back to you with any solution or workarounds we can provide.

thanks, Simon.

PS Apologies i see you have already created ticket 182878, i will follow up on this.