I want to implement the following Win NonLin code into Phoenix using the PML language. Can anyone help with this? I am unable to find the PML reference guiide from the online help portal or from Pharsight web site. Any guidance is much appreciated. Thanks Ranga PS: Code is shown below: MODEL 1 COMMANDS NCON 3 NFUNCTIONS 3 NPARAMETERS 3 PNAMES ‘CLF’, ‘Tabs’, ‘VF’ END TEMPORARY T = X DOSE1 = CON(1) DOSE2 = CON(2) DOSE3 = CON(3) FINF1 = DOSE1/TABS FINF2 = DOSE2/TABS FINF3 = DOSE3/TABS END FUNC1 IF T LE TABS THEN F = (FINF1/(CLF))*(1-DEXP(-(CLF/VF)T)) ELSE F = (FINF1/(CLF))(1-DEXP(-(CLF/VF)TABS))DEXP(-(CLF/VF)(T-TABS)) ENDIF END FUNC2 IF T LE TABS THEN F = (FINF2/(CLF))(1-DEXP(-(CLF/VF)T)) ELSE F = (FINF2/(CLF))(1-DEXP(-(CLF/VF)TABS))DEXP(-(CLF/VF)(T-TABS)) ENDIF END FUNC3 IF T LE TABS THEN F = (FINF3/(CLF))(1-DEXP(-(CLF/VF)T)) ELSE F = (FINF3/(CLF))(1-DEXP(-(CLF/VF)*TABS))DEXP(-(CLF/VF)(T-TABS)) ENDIF END EOM
Ranga, I am guessing you mean Tabs as Time of absorbtion? Have you attended one of the Introduction to Phoenix courses? Do you recall the model writing exercise to look at a Zero-order absorbtion capsule? Please see the attached PDF to create this simple model in Phoenix and then see how you might need to change it. Simon. [file name=zero_order.pdf size=187328]Certara | Drug Development Solutions Remember upcoming public courses are listed here; Certara | Drug Development Solutions US then RoW and onsite courses can be customised for your departments needs.zero_order.pdf (183 KB)
Simon, Thanks for the reply. I was able to get this to work for one dose. But how does one incorporate smulatneous fitting of multiple dose groups? Will that be dosepoint (A2, duration = Tabs) dosepoint (A3, duration = Tabs) or does the above indicate compartments 2 and 3? Ranga
Ranga, The beauty of phoenix modelling language is you do not need to code for multiple dosing, just supply the dose events in the input. If you truly want to dose to different compartments then yes you can add a dose point to each compartment, but from your description I didn’t think you were trying to do that. Here is a set you can use with the model above and a dose of 20 000ug. Simon. [file name=PK3.xls size=6144]Certara | Drug Development Solutions (6 KB)
Simon, Yes, I understand with PML you can add dose events to show multiple doses. But now, I want to simulaneously model data from single dose of 10mpk, 30 mpk and 100 mpk using common parameters such as Tabs, CL and Vss. How do you get that done? Ranga
If there are different doses to different subjects, you can simply run in population mode (naive pooled is available without NLME license) Or are these doses given to the same subject at the same time? to different sites? Perhaps it would be easier if you can post a representative project, PS I am popping out now so won’t see your reply probably. Simon
Simon, I used the population mode to solve my question. Thanks. How can I get %CV in the ouput data? I am getting only SE & %SE being reported. Ranga