Pirana 3.0’s installation includes RsNLME and can be downloaded via
http://lp.certara.com/WFDownloadPirana.html
Pirana licenses are free for academics and you can read more about Pirana through our new online help files;
https://onlinehelp-dev.certara.com/pirana/3.0.0/index.html,
There will also be some addtional “What’s New” tutorial videos added to the existing complimentary course;
https://www.certarauniversity.com/store/694091-118-tu-pirana-tutorial
Simon.
If you are using NONMEM’s SAEM or IMP with Pirana please be aware that the although normally estimates with red text are used to indicate that the final gradient was zero (Pirana Help),
However, for these two estimation methods SAEM and IMP, NONMEM does not output the gradient information (as no direct optimization is needed for mu-modeled theta and Omega).
So, since it is missing, Pirana (incorrectly) displays these values in red. We will fix this and provide further clarification in Pirana help, but for now, any estimates in red displayed for methods SAEM and IMP should be ignored.
This tip has already been pasted to the Support Knowledgebase which you can search here after logging in to support site; https://certara.service-now.com/csm
Also please follow this forum and topic to be kept aware of new features and so forth,
Simon.
there are some great training resources at https://certara.github.io/R-Certara/
PML library of models including Jumbe, Simeoni, Transit
Earlier this month there was a small maintenance release to RsNLME; 1.1.1 which you can read about here;
https://certara.github.io/R-RsNLME/articles/release_notes.html
and also NLME-Engine-21.11.2 for which you can request the new version via; https://certara.github.io/R-RsNLME/articles/installation.html
Simon
What is New in Pirana 24.9.1: https://certara.zoom.us/webinar/register/WN_VedGXbfYR5O0YhwxoNBVuA
Phoenix User Journey: Practical Application of RsNLME – Part 2: https://certara.zoom.us/webinar/register/WN_Hb7eJWuhR7Gp_olVyolkMg
Simon.