This is a PK 2 compartment IV bolus model that handles observations below the quantification limit (BQL). The model is fit using the Laplacian method. For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.
NONMEM to NLME Translation PK 2comp IV bolus BQL Laplacian.pdf (1.39 MB)2Comp_IV_Bolus_BQL_Laplacian.phxproj (1.74 MB)