PK 3 Compartment IV Bolus QRPEM/IMP

This is a PK 3 compartment model with IV bolus administration and clearance parameterization.

In NLME, the model engine is Quasi-Random Parametric Expectation Maximization (QRPEM). For details about QRPEM, refer to Phoenix Help > Contents > Phoenix Model > Phoenix Model Run Modes, Engines, and Output > Phoenix Model Engines > QRPEM.

In NONMEM, the model engine is Importance Sampling (IMP) EM.

For model translation information, refer to the attached slide deck.

[attachment=3096:NONMEM to NLME Translation PK 3comp IV Clearance QRPEM IMP.pdf]

The model is run in both NLME and NONMEM in the attached Phoenix project file.

[attachment=3097:3Comp_IV_bolus_clearance_QRPEM_IMP.phxproj]
NONMEM to NLME Translation PK 3comp IV Clearance QRPEM IMP.pdf (1.31 MB)3Comp_IV_bolus_clearance_QRPEM_IMP.phxproj (2.68 MB)