Quantitative comparison of NONMEM models

Phoenix Certara Forums NLME-NONMEM model comparisons
1

Dear all

I am interested in quantitatively comparing the results of different POPPK studies for a certain drug. Each study reports the value of the pharmacokinetic parameter (e.g. clearance) and the standard error of estimated clearance, the value of estimated inter-individual variability in clearance and its standard error.

Q1) How can we judge the superiority of those models based above parameters i.e.

Model A HIGH IIV: CL= 1 L/kg, SE in CL=0.05, (OMEGA)^2=0.55 IIV 74%, SE OF OMEGA=0.001

OR

Model B High imprecision in IIV estimation: CL=1.2 L/KG SE in CL=0.04, (OMEGA)^2=0.02 IIV 14%, SE OF OMEGA=.06 (RSE 300%)

Q2) How can we present all these data together graphically? any examples?

Many thanks

2

Dear Mondermm,

What was the purpose of the models ? Model A might be better than Model B for a specific purpose e.g. predicting Cmax while Model B can be better for predicting AUC.

I am not sure what is the value of comparing two models developed on different datasets and with potentially different purposes.

A Model with higher uncertainty might be worst than another for the purpose of simulation of new trials but again all depend on what it the application you are after.

SM

3

Dear smouksassi

Thanks for your kind reply. We are comparing all the models have been developed for optimizing dosing by explaining the IIV with covariates.

Many thanks