Simulation results do not match

Phoenix Certara Forums Modelling and Simulation
1

Hi all,

I met some problems when I tried to do a simulation using a final PD model.

Some background information are as follows.

Two intravenous infusions and a washout-between.

Data include response-time profile (0-5 hr)

The PD model is fine (actually it is from Dr. Dan’s book).

I tried to use this final PD model to simulate the response-time curve after a single constant rate iv infusion (the 1st dosing in the final PD model). My steps are as follows:

  1. copy and paste the final PD model

  2. change the dosing to only a single iv infusion

  3. accept all the parameter

  4. set the run option

But the result are very strange (simulation and lnd simulation). From the raw data, we can see the baseline should be around 2.8. But from the simulation table, we can see the E=0.01488 when time is 0. Please see more detail in the project file attached.

All input is appreciated!

LLLi

Simulation.phxproj (657 KB)

2

Dear LLLi

you did everything right. You need to upgrade your version to 70.

I ran your model and got the right simulation results with 70.

I guess you have the previous version which had a bug.

Best Regards

Serge