Simulation results of different dosing

Phoenix Certara Forums NLME-NONMEM model comparisons
1

Hello all,

I request your kind opinion on the following,

I have simulated a PKPD data from lower dose to higher dose, after simulation i am getting the results of time varying concentration with respect to PK. However for PD i am getting the same value through out the time points for each subject.

What could be the possible reason? Is it due to any data mapping issue?

Attached screenshot for your reference.

Thanks for your opinion.

Thanks

Sundar. M

simulation.png
simulation.png1094×621 126 KB

2

HArd to tell from just a screen grab, although I can see a Warnings tab. would it be possible to post you project?

3

we need more info

probably a unit or EC50 value problem you seem to have an all or none effect

4

Hi

Uploaded the project file for evaluation.

Thanks

Sundar. M

Simulation - high dose.phxproj (382 KB)