Two absorption compartment and ADDL

Phoenix Certara Forums Modelling and Simulation
1

Hi,

I am modeling a compound that has mix of IR and SR formulations. The data are from a clinical trial with three times administration a day and sampling at day 18. I defined two absorption compartment with Tlag on the second one. The problem is when I use ADDL the Ka2 appears after Ka1 (cycle time 48 h). however, when I use actual time of administration (as single dose) Ka1 and Ka2 are at their correct time. I would appreciate it if you help me with this issue. How can I use delta time to count for cycle time of 24 hours without giving Ka2 after Ka1. I would like to have them at the right time of administration.

(model is attached)

Kind regards

Amir

2

Hi Amir,

Thanks for reaching out. We did not receive the project file - could you please attach it again or you could e-mail to support@certara.com.

Thanks

Mouli

3

Hi Mouli,

Sorry I forgot to press attach at the end. Now, I think you get it.

Best

Amir

ADDL or Not.phxproj (231 KB)

4

Hi Amir,

I have attached the project file for you. I have split the data and did the analysis for one subject. For each formulation I created a row (see NBI_OPC_1722_10011001 from Split).

Please have a look and let me know if this is what you are looking for.

If you need some further clarification please reachout to us on support@certara.com and I shall organise for a quick teams session.

Thanks

Mouli

2023 Mar_Forum_ADDL or Not.phxproj (1.96 MB)

5

adding link to the ADDL documentation

https://onlinehelp.certara.com/phoenix/8.3/index.html#t=topics%2FMore_on_ADDL.htm&rhsearch=ADDL&rhhlterm=ADDL&rhsyns=%20

please have a special look at Specifying steady state and additional doses outside of the user interface
sscol(SS)
iicol(II)
ssoffcol(SSOffset)