Dear All,
How to estimate / model whether a drug is following a zero order absorption ?
Plz help me with an example model…
Thanks in advance,
Raghav
Hi Raghav, typically I find this when a simple absorption model fails to describe the data well, even if I add a Tlag; e.g. try fitting the following data with a 1 compartment model and First order absorption.
Here in the Linear plot you see Cmax (orTmax) is not captured well by the built in model PK4.
Parameter Estimate Units Stderr CV%
tvV 96.135 L 9.5470414 9.9308695
tvKe 0.466347 1/h 0.0549163 11.775845
zrate 4399.97 ug/h 200.89798 4.5658944
stdev0 5.38137 1.0983624 20.410461
Simon.
PS This example comes from this text book http://www.certara.com/pk-pd-textbook and is covered in our Intro to Phoenix WinNonlin course should you get the opportunity to attend one of those;
https://www.certara.com/training or in India/SE Asia contact Venkateswari Muthukrishnan Venkateswari.Muthukrishnan@certara.com directly.
PK3.xls (6 KB)