Does anyone have and example trying to fit a inverted u shaped dose response model?, assuming both a stimulatory and inhibitory binding site to account for the biphasic. This would be akin to PD17 from Gabrielsson and Weiner text.
I am having issue with the actual inputs, and would like to see how these were arranged within an ASCII format.
Dear Colleague,
Since PD17 is not NLME per se, I think you can get some global minimum, but be aware of overparameterization!
E = E0 - Imax1 * C^n1 / (IC501^n1 + C^n1) - Imax2 * C^n2 / (IC502^n2 + C^n2) + Emax1 * C^n3 / (EC501^n3 + C^n3) + Emax2 * C^n4 / (EC502^n4 + C^n4)
IMHO you need strong arguments to split the phases.
Sorry, didn’t get a chance to implement it somewhere…
BR,
Mittyright