NLME error population PK model

General
1

Hi All, I just recently run NLME in Phoenix and got below error.

Error in Population:
Error reading file C:\Users\HARIKR~1.DEV\AppData\Local\Temp\1\Phoenix\DME_SI~1.605\out000001.txt: File does not exist

There are errors during model execution.

is this file created by model and not saved and accessible to execute the model? How to fix it.

Thank you so much in advance.

2

this could be caused by an issue with the data file, or by your installation. I recommend that you email your project to support@certara.com

Simon.

3

Thank you for your reply. I did re-install the software and still getting the same error.

4

Hi Simon, My email doesn’t allow to send out attachments. Is there a way to upload my workflow here? Thanks

5

you can create a support ticket directly in the portal; Certara Product Support - Jira Service Management

6

Thank you. Uploaded phx nlme workflow in the portal. Hope it will be fixed soon.

1 Like
7

can you share the pml code are your trying to freeze an epsilon ? can you reproduce the error on a different dataset ?

8

Initially i tried with data from 5 subjects and same error found in executing the model.

Below is the model text. Thanks

test(){
cfMicro(A1, Cl / V, Cl2 / V, Cl2 / V2, first = (Aa = Ka))
dosepoint(Aa)
C = A1 / V
error(CEps = 1)
observe(CObs = C + CEps * sqrt(1 + C^2 * (CMultStdev/sigma())^2))
stparm(Ka = tvKa * exp(nKa))
stparm(V = tvV * exp(nV))
stparm(V2 = tvV2 * exp(nV2))
stparm(Cl = tvCl * exp(nCl))
stparm(Cl2 = tvCl2 * exp(nCl2))
stparm(CMultStdev = tvCMultStdev)
fixef(tvKa = c(0, 0.5725, ))
fixef(tvV = c(0, 0.016, ))
fixef(tvV2 = c(0, 0.01, ))
fixef(tvCl = c(0, -0.1, ))
fixef(tvCl2 = c(0, 0.001, ))
fixef(tvCMultStdev = c(0, 0.59269079444988, ))
ranef(diag(nV, nCl, nKa, nV2, nCl2) = c(1, 1, 1, 1, 1))
}

9

why is the initial estimate for tvCl negative ?

10

Error could be your Temp File issue