Hi: I am a brand new TS user. I simulated profiles from two doses in a total of 100 subjects using the example of Simuline from the course. I would like to take the example further by: 1. Getting the AUC for all subjects to plot as a box-plot 2. Identifying the percentage of subjects who have concentrations above say 2 ug/mL in the low dose group and 4 ug/mL in the high dose group. It appears that the only option for me to get the AUC is to save the simulation results (timeseries grid) in excel and then calculate the PK parameters using WinNonlin. Is there another way? Comments appreciated.
Hi guruchan, I just joined the forums and saw your post. I’m not familiar with the Simuline example but think you can get AUCs directly from TS with Analysis Plan, Summarization, Partial Area Under the Curve, though in my experience this is a very slow calculation. But if you just want steady-state AUC = dose/CL, and CL is lognormal(mu,sigma) i.e. ln(CL) is normal(mu,sigma), then AUC is lognormal(ln(dose)/mu, sigma), or you can simulate it directly in Excel with dose/LOGNORMDIST(RAND(),LN(tvCL),sigma). To get the proportion of subjects who meet a criterion like C(t)>2, where t is an observation time, you could set up an Action at Times block with time set to t and action to set a variable to an expression like (Cp > Threshold), which is 1 or 0. Just observe this variable and add an Analysis Plan method (Descriptive Statistics) that takes the average of the observations, which will be the proportion of subjects with a 1. I hope this helps. Bill Poland Pharsight Sunnyvale, CA