I have conducted a popPK model with steady state. In our study, oral drug A is given to subjects once daily for 2 weeks before PK sampling. Then, blood samples are collected at pre-dose and at 1, 2, 4, 6, 8 hours after drug intake. VPC results indicated that final structural model fitted the data well.
I want to use this model for AUC calculation and dose simulation. However, I met some issues when using this steady-state model for AUC calculation, warning some subjects are unable to achieve steady-state. I’m not sure if I have used a right method for AUC calculation. It will be much appreciated if someone can give me some suggestions. I have attached my document. Looking forward to your kind replies! Drug A.phxproj (6.5 MB)