PKPD: 1 Compartment-IV Infusion - Emax with Baseline, Shape and Effect

Phoenix Certara Forums NLME-NONMEM model comparisons
1

This is a PKPD model with 1 compartment IV infusion for PK and an Emax model with baseline, shape factor and effect compartment for PD.

For model translation information, refer to the attached slide deck. The model is run in both NLME and NONMEM in the attached Phoenix project file.

NONMEM to NLMR Translation 1comp IV infusion Emax Bl_s_Eff.pdf (1.52 MB)

1Comp_IV_infusion_emax_bl_s_eff.phxproj (1.02 MB)

2

I am running Phoenix 6.3.0.395 and cannot open the provided .phxproj file because of the version difference. Can you please make it backward compatible? Thanks!

3

Sorry, this is a pretty old version that we do not support anymore. The project file can easily be created in earlier versions using the source files. Here you have:

the dataset:

pkpd_link.xls (23.5 KB)

the NONMEM control file:

1c_iv_infusion_emax_bl_s_eff_nonmem.rtf (1.35 KB)

the PML code for the Phoenix Model object:

1c_iv_infusion_emax_bl_s_eff_pml.rtf (36.9 KB)