PML codes for a precursor model

Phoenix Certara Forums PML School
1

Hi,

I’m working on using Phoenix WinNonlin 8.2 on a PKPD model project. The model scheme is in the attached figure. I used IDR in Phoenix model to work out the part in the red box. To move forward, it seems I need to use PML codes. Could you give me some guidance on this? I’ve also include my IDR codes below.

Thanks,

-Mike

test(){
deriv(E = Kin * (1 + Emax * C / (C + EC50)) - Kout * E)
cfMicro(A1, Cl / V, first = (Aa = Ka))
dosepoint(Aa)
C = A1 / V
sequence{E = Kin / Kout}
error(EEps = 0.1)
observe(EObs = E * (1 + EEps))
stparm(Ka = tvKa)
stparm(V = tvV)
stparm(Cl = tvCl)
stparm(Kin = tvKin)
stparm(Kout = tvKout)
stparm(Emax = tvEmax)
stparm(EC50 = tvEC50)
fixef(tvKa(freeze) = c(, 3, ))
fixef(tvV(freeze) = c(, 47.584317, ))
fixef(tvCl(freeze) = c(, 1.6311257, ))
fixef(tvKin = c(, 0.00062, ))
fixef(tvKout = c(, 0.0066, ))
fixef(tvEmax = c(, 803, ))
fixef(tvEC50 = c(, 2.9, ))
}

model_scheme.jpg
model_scheme.jpg840×653 44 KB

2

I made some progress but the model can’t go through. There is an error message. Please help take a look on the Phoenix file and error message here.

Thanks!

precursor model.phxproj (419 KB)

error message.png
error message.png505×217 4.9 KB

3

Hello Mike,

I think the problem is that you have a 2 EEps parameters (the same name) for both observation blocks. I renamed one EEps to EEps2 and the model seems to run fine. Give it a try.

Ana

4

Hi Ana,

It worked!

Thanks,

Mike