This is Population PKPD model. The PK is a 2 compartment extravascular model with clearance parameterization, with multiple Doses (every 12 hours for 84 days). The PD is an Emax model with the effect depending on the cumulative AUC from t=0 to t=t. The Emax is found using the logistic function, ilogit. The overall model is fit using First Order Conditional Estimation (FOCE).
For model translation information, refer to the attached slide deck.
[attachment=3116:NONMEM_NLME_TRANSLATION_PPK_PD_with_Emax_dependent_on_AUC_FOCE.pdf]
The model is run in both NLME and NONMEM in the attached Phoenix project file.
[attachment=3117:2Comp_Multiple_Oral_Dose_PK_with_Emax_dependent_on_AUC.phxproj]
NONMEM_NLME_TRANSLATION_PPK_PD_with_Emax_dependent_on_AUC_FOCE.pdf (791 KB)2Comp_Multiple_Oral_Dose_PK_with_Emax_dependent_on_AUC.phxproj (1.59 MB)