Hi,
I have some questions about the paper of dose proportionality published by Smith in 2000. My original question was posted here (https://support.certara.com/forums/topic/836-dose-proportionality/) but it looks like that nobody noticed it. So I posted my questions here.
In this paper, the authors mentioned 4 models for dose proportionality. Is there any rule to choose the model for different studies? Can someone provide more information about the saturable elimination model vs power model? If we don’t know whether the nonlinear PK exists or not, is it safer to use the saturable elimination model than to use power model first?
Any input is appreciated!
Thank you!
LLLi