How do I convert clearance values from mg/(hr*uM)/kg to mL/min/kg and volumes from mg/(uM)/kg to L/kg? The unit builder is unable to convert the imported plasma concentrations from uM to ug/mL.
Jason, WinNonlin looks at “uM” as uMoles i.e. an amount, so you will need to do two steps in a Data Wizard object at the start of your analysis. Step 1 Col Prop : Specify the units of conc to be uM/L this will change the attributes of the column to a Molar conc, (numbers won’t change at this step). Step 2 Col Prop : Now Convert the units to ug/mL feed the results of this to everything else in your workflow, Tip: (if you “right-click” in your workflow diagram and “Connect External sources to Data links” before making the data wizard detailed above it’s very easy to re-link it to the corrected concentration column.) Simon.
Thank you, Simon. However, I still am unable to convert units. In a Data Wizard object unit builder, the following occurs: “Concentration (umol/L) => (ug/mL) (Molecular Weight = 429.50)” Execute step "Failed to execute. Reason: It is not possible to convert from old unit ‘umol/L’ to new unit ‘ug/mL’. It appears that the molecular weight information is not retained because unit builder now says, “Concentration (umol/L) => (ug/mL) Unit Convert”
Jason, Are you able to send us (e.g. Support@pharsight.com) the project to see if we can resolve this for you. There is a known issue (QC_PHX11927) that reports this problem in certain circumstances, although I personally haven’t seen it if I make sure to leave the cell and click somewhere else before F7(execute) and this seems to force the mol wt to be explicitly ‘submitted’ to the data grid behind. Also there is a Workaround: Use a Column Transformation step to manually do the conversion. For example: To convert from g to mol, use the Transformation x/n, where n is the molecular weight. To convert from mol to g, use x*n, where n is the molecular weight. Please let us know how you get on, Simon.